Diphenhydramine Hydrochloride

  • Diphenhydramine Hydrochloride
Name:Diphenhydramine Hydrochloride
Appearance:White crystalline powder
Package:25kg/fiber drum
Acidity or alkalinity:0.5ml of 0.01M NaOH max
Loss on drying:0.5% max
Residue on ignition:0.1% max
Impurity A:0.5% max
Impurity B:0.3% max
Impurity C:0.3% max
Impurity D:0.3% max
Impurity E:0.3% max
Assay:98.0-102.0%(dried)
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Binhong Industry Co., Ltd.

Product Description

Diphenhydramine hydrochloride is an antihistamine drug having the chemical name 2-(Diphenylmethoxy)- N,N-dimethylethylamine hydrochloride. It occurs as a white, crystalline powder, is freely soluble in water and alcohol and has a molecular weight of 291.82. The molecular formula is C17H21NO·HCl 


Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative side effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells. Diphenhydramine hydrochloride in the injectable form has a rapid onset of action. Diphenhydramine hydrochloride is widely distributed throughout the body, including the CNS.


Diphenhydramine hydrochloride in the injectable form is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when diphenhydramine hydrochloride in the oral form is impractical.

antihistaminic: For amelioration of allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled, and for other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated.

Motion Sickness: For active treatment of motion sickness.

Antiparkinsonism: For use in parkinsonism, when oral therapy is impossible or contraindicated, as follows: parkinsonism in the elderly who are unable to tolerate more potent agents; mild cases of parkinsonism in other age groups, and in other cases of parkinsonism in combination with centrally acting anticholinergic agents.

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